2,5-Dihydroxy benzoic acid
2,5-Dihydroxy benzoic acid
CAS: 490-79-9
Molecular Formula: C7H6O4
2,5-Dihydroxy benzoic acid - Names and Identifiers
| Name | 2,5-Dihydroxy benzoic acid |
| Synonyms | 2,5-Dhba Gentisic acid kyselinagentisinova Kyselina gentisinova 2,5-Dioxybenzoic acid 2,5-dihydroxybenzoate MesalaMine IMpurity G 5-hydroxysalicylicacid 5-hydroxy-salicylicaci 5-Hydroxysalicylic acid 2,5-dihydroxy-benzoicaci 2,5-dihydroxybenzoic acid acido2,5-diidrossibenzoico Hydroguinonecarboxylicacid 2,5-Dihydroxy benzoic acid Salicylic acid, 5-hydroxy- Hydroquinonecarboxylic acid Benzoic acid, 2,5-dihydroxy- kyselina2,5-dihydroxybenzoova Kyselina 2,5-dihydroxybenzoova |
| CAS | 490-79-9 |
| EINECS | 207-718-5 |
| InChI | InChI=1/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 |
| InChIKey | WXTMDXOMEHJXQO-UHFFFAOYSA-N |
2,5-Dihydroxy benzoic acid - Physico-chemical Properties
| Molecular Formula | C7H6O4 |
| Molar Mass | 154.12 |
| Density | 1.3725 (rough estimate) |
| Melting Point | 204-208°C(lit.) |
| Boling Point | 237.46°C (rough estimate) |
| Flash Point | 214°C |
| Water Solubility | soluble |
| Solubility | Soluble in methanol, acid water |
| Vapor Presure | 2.38E-07mmHg at 25°C |
| Appearance | White powder or crystal |
| Color | White to light beige |
| Merck | 14,4398 |
| BRN | 2209119 |
| pKa | 2.97(at 25℃) |
| PH | 3.21(1 mM solution);2.56(10 mM solution);2.01(100 mM solution) |
| Storage Condition | Store below +30°C. |
| Sensitive | Sensitive to light |
| Refractive Index | 1.6400 (estimate) |
| MDL | MFCD00002460 |
| Physical and Chemical Properties | melting point 204-207°C water-soluble solution |
| Use | Used as a pharmaceutical Intermediate |
2,5-Dihydroxy benzoic acid - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| RTECS | LY3850000 |
| TSCA | Yes |
| HS Code | 29182990 |
| Hazard Note | Harmful |
2,5-Dihydroxy benzoic acid - Reference
| Reference Show more | 1. Zhao Mengmeng, Zhang Wengang, Gubin, Yang Xijuan, Zhang Jie, gan Shengzhi. Effects of superfine grinding on polyphenol composition and antioxidant activity of highland barley bran powder [J]. Journal of Agricultural Engineering, 2020,36(15):291-298. 2. [IF = 7.514] Xiao Ming Yu et al."Impact of processing technologies on isoflavones, phenic acids, and antioxant capabilities of soy milk prepared from 15 soy bean variables." Food Chem. 2021 May;345:128612 3. [IF = 4.879] Yang Liu et al."UV-B Radiation largeley Promoted the Transformation of Primary metabliites to disorders in Astra." Biomolecules. 2020 Apr;10(4):504 |
2,5-Dihydroxy benzoic acid - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Properties | 2, 5-dihydroxybenzoic acid is also known as 5-hydroxysalicylic acid, commonly known as DBH is also called gentilic acid, which is a polyhydroxycarboxylic acid, which is a secondary product of salicylic acid after renal metabolism. 2, 5-dihydroxybenzoic acid is a white needle crystal, soluble in hot water, ethanol and ether, insoluble in chloroform, benzene and carbon disulfide. When heated for a long time above 150 ℃, it will decompose into carbon dioxide and hydroquinone, which is unstable in the air and blue in case of ferric chloride. |
| uses | 2,5-dihydroxybenzoic acid is a hydroquinone compound, which is prone to oxidation reaction and is commonly used as an antioxidant excipient in the pharmaceutical industry. 2, 5-dihydroxybenzoic acid is also an antipyretic analgesic and an important pharmaceutical intermediate. 2, 5-dihydroxybenzoic acid is also a matrix commonly used in matrix-assisted laser desorption ionization mass spectrometry, and its application is very wide. Used in organic synthesis. Medicine. Aspirin metabolites. Gentilic acid itself is an antipyretic analgesic and also used as a pharmaceutical intermediate. |
| Production method | It is obtained by hydroxylation of hydroquinone. |
Last Update：2024-04-09 20:49:11
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View History
2,5-Dihydroxy benzoic acid
p-Chloro-N-[3-(dimethylamino)propyl]thiobenzamide
4-氨基-3-甲氧基苯甲酸
3-ethoxy-4-[(4-fluorophenyl)methoxy]benzoic acid
2-Propen-1-one, 3-(phenylmethoxy)-1-[(3aS,6R,7aR)-tetrahydro-8,8-dimethyl-2,2-dioxido-3H-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-, (2E)-
2-氟-5-硝基联苯
3-Fluoro-4-nitrobenzoic acid methyl ester
Formamidine Hydrobromide
5-METHYLAMINOMETHYL-2,4-DIHYDRO-[1,2,4]TRIAZOL-3-ONE HYDROCHLORIDE
((2S,4S)-4-氟-1-甲基吡咯烷-2-基)甲醇
p-Chloro-N-[3-(dimethylamino)propyl]thiobenzamide
4-氨基-3-甲氧基苯甲酸
3-ethoxy-4-[(4-fluorophenyl)methoxy]benzoic acid
2-Propen-1-one, 3-(phenylmethoxy)-1-[(3aS,6R,7aR)-tetrahydro-8,8-dimethyl-2,2-dioxido-3H-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-, (2E)-
2-氟-5-硝基联苯
3-Fluoro-4-nitrobenzoic acid methyl ester
Formamidine Hydrobromide
5-METHYLAMINOMETHYL-2,4-DIHYDRO-[1,2,4]TRIAZOL-3-ONE HYDROCHLORIDE
((2S,4S)-4-氟-1-甲基吡咯烷-2-基)甲醇